Degenerate Ring Transformations of Heterocyclic Compounds by Henk C. van der Plas (Eds.)

By Henk C. van der Plas (Eds.)

Demonstrated in 1960, Advances in Heterocyclic Chemistry is the definitive serial within the area--one of significant value to natural chemists, polymer chemists, and plenty of organic scientists. Written by way of tested gurus within the box, the great reports mix descriptive chemistry and mechanistic perception to yield an figuring out of the way the chemistry drives the houses. Degenerate ring differences of heterocycles are categorized as reactions during which a heterocyclic method is switched over into an identical heterocyclic procedure. This monograph covers an authoritative, complete evaluation of a bunch of degenerate ring variations in 5- and 6-membered heterocycles. It indicates how by way of 15 N-labeled, 13 C-labeled, or selectively substituted compounds those degenerate rign changes might be came upon and the way many of the effects will be defined by means of the Addition Nucleophile, Ring establishing, and Ring Closure [ANRORC] mechanism. one other major subject of the monograph is the prevalence of degenerate ring variations.

Show description

By Henk C. van der Plas (Eds.)

Demonstrated in 1960, Advances in Heterocyclic Chemistry is the definitive serial within the area--one of significant value to natural chemists, polymer chemists, and plenty of organic scientists. Written by way of tested gurus within the box, the great reports mix descriptive chemistry and mechanistic perception to yield an figuring out of the way the chemistry drives the houses. Degenerate ring differences of heterocycles are categorized as reactions during which a heterocyclic method is switched over into an identical heterocyclic procedure. This monograph covers an authoritative, complete evaluation of a bunch of degenerate ring variations in 5- and 6-membered heterocycles. It indicates how by way of 15 N-labeled, 13 C-labeled, or selectively substituted compounds those degenerate rign changes might be came upon and the way many of the effects will be defined by means of the Addition Nucleophile, Ring establishing, and Ring Closure [ANRORC] mechanism. one other major subject of the monograph is the prevalence of degenerate ring variations.

Show description

Read Online or Download Degenerate Ring Transformations of Heterocyclic Compounds PDF

Best chemistry books

Advances in Heterocyclic Chemistry, Vol. 19

The current quantity contains 4 chapters. the 1st (by Ollis and Ramsden) classifies and discusses the chemistry of that fascinating staff of compounds often called meso-ionic heterocycles and incorporates a worthy basic definition of the time period. the second one bankruptcy (Litvinov and Gol'dfarb) offers with structures with (or extra) thiophene (or selenophene) jewelry without delay fused jointly.

Advanced Fluorescence Reporters in Chemistry and Biology II: Molecular Constructions, Polymers and Nanoparticles

From the reviews:“This ebook is a finished evaluation of the different sorts of nanoscale probes which have been and are presently being constructed for sensing of analytes. The well timed reference part permits the reader to find key references to the first literature for enlargement of the cloth coated.

Chemistry and Technology of Water Based Inks

This booklet has been many years within the making. considering its starting the concept that has been subtle repeatedly. it is a first try out at a technical publication for me and luckily the objectives i've got set were completed. i've been focused on water dependent ink evaluate on the grounds that its uncertain commence­ nings within the early Nineteen Seventies.

Extra info for Degenerate Ring Transformations of Heterocyclic Compounds

Sample text

It has been argued that the loss of the hydrogen bromide in 53, leading to 54, has to take place before cyclization. This is based on the observation that in the retrieved starting material no decrease of the 15N content was observed. If cyclization would have taken place before loss of the hydrogen bromide, then the 1 : 1 C-6 amino adduct 55 would have been formed, which is in equilibrium with the starting material, and a decrease of the 15N content in the retrieved starting material should have been found.

It is evident that the isoquinoline ring is more inclined to a nucleophilic addition than the pyridine ring. It is of interest to mention that 2-bromoquinoline, when treated with potassium amide in liquid ammonia, reacts very differently from 3bromoisoquinoline; hardly any 2-aminoquinoline is obtained, but as main product 2-methylquinazoline has been isolated (65RTC1569; 67RTC187). 10). Since this ring transformation cannot be considered degenerate, it is beyond the scope of this book to discuss this reaction in more detail.

15N-Labeling studies are necessary to establish more firmly the reaction course of the aminolysis. 4 PERCENTAGES OF SN(ANRORC) PARTICIPATION IN THE AMINATION OF 2-BROMO-6-PHENYL- AND 4-BROMO-6PHENYLPYRIMIDINES AND THE CORRESPONDING 2-BROMO4,6-DIPHENYL- AND 4-BROMO-2,6-DIPHENYLPYRIMIDINES d. Aminolysis of Pyrimidines Containing a Leaving Group at C-2 Different from Halogen The results of the studies on aminodehalogenation presented in previous sections induced investigations of the influence of C-2 substituents with leaving group mobilities different from halogen on the occurrence of the SN(ANRORC) process during amination with potassium amide/liquid am monia.

Download PDF sample

Rated 4.68 of 5 – based on 26 votes